Theoretically, they may want to select probiotic supplements that do not contain histamine-producing bacteria, but to date, there has been no research on this specific area. People with a histamine intolerance should avoid foods that contain excess histamine ( 28). The excess histamine is then absorbed through the lining of the intestinal tract and into the bloodstream, causing symptoms similar to an allergic reaction ( 27). However, some people with histamine intolerance have trouble properly breaking down the histamine in their bodies, seeing as they do not produce enough DAO ( 24, 25, 26). This enzyme inhibits histamine levels from rising enough to cause symptoms ( 23). Normally, histamine that is produced in your digestive tract is naturally degraded by an enzyme called diamine oxidase (DAO). This process creates redness and swelling in the affected area, and can also trigger allergy symptoms such as itching, watery eyes, runny nose or trouble breathing. The vessels also become more permeable so that immune cells can easily get into the relevant tissue to combat any pathogens ( 22).
When histamine levels rise, blood vessels dilate to bring more blood to the affected area.
Histamine is a molecule that is normally produced by your immune system when it detects a threat. Some bacterial strains used in probiotic supplements can produce histamine inside the digestive tract of humans ( 19, 20, 21). Some people may experience headaches after eating these foods, and should instead opt for probiotic supplements. Summaryįermented foods rich in probiotics naturally contain amines. If probiotic-rich foods trigger your symptoms, a probiotic supplement may be a better choice.
Keeping a food diary including any headache symptoms you might experience can help clarify whether fermented foods are problematic for you. More research is needed to determine whether or not amines can be direct triggers of headaches or migraines in some people. However, a review of 10 controlled studies found no significant effect of dietary amines on headaches ( 17, 18). One study found that low-histamine diets reduced headaches in 75% of participants. The most common amines found in probiotic-rich foods include histamine, tyramine, tryptamine and phenylethylamine ( 14).Īmines can excite the central nervous system, increase or decrease blood flow and may trigger headaches in people sensitive to the substance ( 15, 16). Some probiotic-rich foods, like yogurt, sauerkraut and kimchi, contain biogenic amines ( 11, 12).īiogenic amines are substances that form when protein-containing foods age or are fermented by bacteria ( 13).
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